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President Obama?s proposed 2013 budget seeks to reduce the federal deficit to $901 billion. He seeks to achieve this goal by increasing taxes on ?the wealthy? ? households making more than $250,000. The goal is to alleviate the deficit over the next ten years by bringing an additional $1.5 trillion into government coffers.
Big deficits lead to higher taxes, which are a drain on enterprise, particularly small business. However, many small business owners pay taxes on their profits at the individual level. An annual income of $250,000 may initially seem like a lot of money, but in places like the New York, Boston and San Francisco metropolitan areas, it doesn?t necessarily qualify you as ?rich.?
The good news for smaller companies is that President Obama has proposed a 3 percent increase in the Small Business Administration (SBA) budget, raising it to $949 million. The bulk of the money will go toward subsidizing government-guaranteed loans to small businesses. Without a greater government subsidy, the SBA would have to increase fees on borrowers and lenders, a move that could stymie the fragile economy.
Although the president is suggesting a $16 billion cap on the size of the SBA?s flagship 7(a) loan program ? lower than the current $17.5 billion cap ? the agency would received an additional $7 million for an entrepreneurship training program for veterans. However, the SBA would have to reduce funding for its other counseling programs, including its nationwide network of Small Business Development Centers. These centers have proven valuable to the growth of small businesses. I believe this cut is a mistake.
The President has also proposed a $8 billion Community College to Career Fund that could bolster entrepreneurship. This collaborative effort between the Department of Labor and the Department of Education would train more workers for jobs in growing industries and offer a six-week online course to help create up to 500,000 new entrepreneurs, as well as a six-month entrepreneurship training program available to 100,000 small-business owners. New government programs usually come with bureaucracy. It remains to be seen whether this initiative will make a difference.
Additionally, the budget offers a 2013 tax credit that gives small businesses adding jobs and wages a tax cut equal to 10 percent of wages added up to $500,000. The tax credit would be available only to employers with fewer than 50 full-time workers.
Obama Photo via Shutterstock
About the Author
A frequently quoted expert on small business lending and recently named the ?Top Entrepreneur of 2011? by Crain?s New York Business, Rohit Arora is CEO of Biz2Credit, which connects small business owners with 400 lenders, credit rating agencies and service providers. Since 2007, Biz2Credit has secured $400 million in funding for small businesses across the U.S. via its safe, efficient online platform.
image way href = ?http://www.flickr.com/photos/76583692@N00/5835961424?> Another big, fat, oh-so of the Soviet statues found in Kiev. In the early 1980s the Soviet Union, had the budget deficit, caused by a boycott of the Moscow Olympics in 1980, Lost Empire, tours and the demands of the war in Afghanistan. This has led to spending cuts in many areas, but obviously the construction of statues was hardly affected at all. It is a monument to Russian-Ukrainian friendship, construction 1982.Pour get this photo without having to remove some of the hard, jarring the structure of the background, I practically had to put on your back and pull the ?this angle. Treatment HDR and Topaz certain details, he gives quite a dramatic appearance, whether Do not you think? Thoughts | Comments | Reviews | Questions are always welcome ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ Matt Shalvatis ? off the beaten path Photography Personal Pages: Website | Facebook | Twitter From: HDR Spotting | HDR photographer | Topaz masters ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
photos WanderingtheWorld (www.LostManProject.com) portfolio | Travel Blog HDR | Tumblr | contact me Here is an excerpt from my travel blog. Cheers.Je his grandmother in the kitchen downstairs Christmas morning to spy on the sun breaking through cloud cover in winter. Colors, which made me put on my boots and see what I could find. I was walking on the road and enjoyed the break the silence that is starting to wake up when the sun rises. There is something special in the morning calm, no matter where you are in the world. This is the world wake up. Pours light on the horizon and within a few hours, the landscape is completely different place. The whole process is fascinant.La man walking the road, it?s me ? I like shooting people, and I do not always have someone else to shoot. Car shots you need to create a tripod and timer. A big Chevy truck, which confused people power driven very slowly, at a time when I was taking pictures. I?m sure he assumed I was a tripod of the gun and wondered why I ran in front of it. This path is the path and especially a great pity that he does not often photographers who are crazy about it. I am sure he is always telling the locals what he saw today.
?Stream of Leaves?
United States, New Hampshire, White Mountains, fall time
photos WanderingtheWorld (www.LostManProject.com) portfolio | Travel Blog HDR | Tumblr | contact me Here is an excerpt from my travel blog. Cheers.Un of these days I?m going to kill me. Although you do not see this file, there is a large tree that had fallen over this small river, just behind where I took this picture. While bushwhacking my way through the virgin territory of wood, I saw a bright green moss on the banks of the river across the river and I knew right away that trouble the company. This particular point is the considerable resources of forest gravel road marked on the map. (If a tree falls in a forest and no one has heard it all, it sounds? ?.. One of such places). So I decided to fallen tree across the river. I crawled on all fours in the same way all slippery ? which seemed ridiculous, and he did ok. I do not even see a bright yellow umbrella-shaped tree, before crossing the stream, so it was well worth the effort. Tips: Always wear waterproof shoes or boots when shooting landscapes in the whole (or a rainy night in New York!).
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[unable to retrieve full-text content]AP - At Columbia University and elsewhere, the fear that the New York Police Department might secretly be infiltrating Muslim students' lives has spread beyond them to others who find the reported tactics "disgusting," as one teenager put it.
[unable to retrieve full-text content]Reuters - A senior Japanese Finance Ministry official said the upward pressure on the yen was easing and he saw nothing strange in the currency's movements as it pulls away from record highs below 80 yen versus the dollar.
ADMAA (Lic.2-1027959 & 3-1027958) pr?sente ce concert avec l'after
Chinese Man en concert le 16 mars 2012 de 20h30 ? 04h00 au Rocher de Palmer de Cenon
Le Chinese Man revient avec un nouvel album "Racing with the Sun", Les mix s?impr?gnent de sonorit?s hip-hop, dub, dubstep, drum'n'bass, reggae ou encore jazz, tout en respirant les musiques africaines et indiennes. Le crew compos? de High Ku, SLY et Z? mat cr?e un univers visuel vari?e ? l?image des paysages sonores sans cesse renouvel?s. On se voit propuls? en pleine nouvel Orl?ans avec des morceaux comme ? Get up ?. Les cuivres cr?ent un cot? ? western ? avec des jeux de lumi?res oscillant entre jaune, rouge et oranger. On appr?ciera? le syst?me de camera des DJ?s qui renvoient des images ? live ? de leurs prouesses, comme si le public ?tait propuls? quelques secondes au dessus des platines. En deux mots un live esth?tique et inventif.
sakya+ chinese man+ tha trickaz +skoob et le yan ?l'after c'est de 00h ? 4 h tha trickaz + skoob et le yan?et de 20h30 ? 4h00 dj au bar
[unable to retrieve full-text content]... or a new sound personal injure {lawyer|attorney|lawyer or attorney|attorney or lawyer|law firm|legal professional|attorney at law|legal representative|legal practitioner|lawyers|legal counsel|solicitor|counsel|personal injury ...
[unable to retrieve full-text content]Reuters - LONDON (Reuters)- No sooner are Europe's debt anxieties easing a touch than a sharp rise in oil prices threatens to impede the economy's tentative recovery from the euro's near-death experience with Greece.
[unable to retrieve full-text content]AP - Venezuelan President Hugo Chavez isn't naming a substitute as he prepares to head to Cuba for surgery to remove a potentially cancerous tumor, and he assured supporters on Thursday that he will be around for a long time.
ScienceDaily (Feb. 22, 2012) ? The more afraid a person is of a spider, the bigger that individual perceives the spider to be, new research suggests.
In the context of a fear of spiders, this warped perception doesn't necessarily interfere with daily living. But for individuals who are afraid of needles, for example, the conviction that needles are larger than they really are could lead people who fear injections to avoid getting the health care they need.
A better understanding of how a phobia affects the perception of feared objects can help clinicians design more effective treatments for people who seek to overcome their fears, according to the researchers.
In this study, participants who feared spiders were asked to undergo five encounters with live spiders -- tarantulas, in fact -- and then provide size estimates of the spiders after those encounters ended. The more afraid the participants said they were of the spiders, the larger they estimated the spiders had been.
"If one is afraid of spiders, and by virtue of being afraid of spiders one tends to perceive spiders as bigger than they really are, that may feed the fear, foster that fear, and make it difficult to overcome," said Michael Vasey, professor of psychology at Ohio State University and lead author of the study.
"When it comes to phobias, it's all about avoidance as a primary means of keeping oneself safe. As long as you avoid, you can't discover that you're wrong. And you're stuck. So to the extent that perceiving spiders as bigger than they really are fosters fear and avoidance, it then potentially is part of this cycle that feeds the phobia that leads to its persistence.
"We're trying to understand why phobias persist so we can better target treatments to change those reasons they persist."
The study is published in a recent issue of the Journal of Anxiety Disorders.
The researchers recruited 57 people who self-identified as having a spider phobia. Each participant then interacted at specific time points over a period of eight weeks with five different varieties of tarantulas varying in size from about 1 to 6 inches long.
The spiders were contained in an uncovered glass tank. Participants began their encounters 12 feet from the tank and were asked to approach the spider. Once they were standing next to the tank, they were asked to guide the spider around the tank by touching it with an 8-inch probe, and later with a shorter probe.
Throughout these encounters, researchers asked participants to report how afraid they were feeling on a scale of 0-100 according to an index of subjective units of distress. After the encounters, participants completed additional self-report measures of their specific fear of spiders, any panic symptoms they experienced during the encounters with the spiders, and thoughts about fear reduction and future spider encounters.
Finally, the research participants estimated the size of the spiders -- while no longer being able to see them -- by drawing a single line on an index card indicating the length of the spider from the tips of its front legs to the tips of its back legs.
An analysis of the results showed that higher average peak ratings of distress during the spider encounters were associated with estimates that the spiders were larger than they really were. Similar positive associations were seen between over-estimates of spider size and participants' higher average peak levels of anxiety, higher average numbers of panic symptoms and overall spider fear. These findings have been supported in later studies with broader samples of people with varying levels of fear of spiders.
"It would appear from that result that fear is driving or altering the perception of the feared object, in this case a spider," said Vasey, also the director of research for the psychology department's Anxiety and Stress Disorders Clinic. "We already knew fear and anxiety alter thoughts about the feared thing. For example, the feared outcome is interpreted as being more likely than it really is. But this study shows that even perception is altered by fear. In this case, the feared spider is seen as being bigger. And that may serve as a maintaining factor for the fear."
The approach tasks with the spiders are a classic example of exposure therapy, a common treatment for people with phobias. Though this therapy is known to be effective, scientists still do not fully understand why it works. And for some, the effects don't last -- but it is difficult to predict who will have a relapse of fear, Vasey said.
He and colleagues are studying these biased perceptions as well as attitudes with hopes that the new knowledge will enhance treatment for people with various phobias. The work suggests that fear not only alters one's perception of the feared thing, but also can influence a person's automatic attitude toward an object. Those who have developed an automatic negative attitude toward a feared object might have a harder time overcoming their fear.
Though individuals with arachnophobia are unlikely to seek treatment, the use of spiders in this research was a convenient way to study the complex effects of fear on visual perception and how those effects might cause fear to persist, Vasey noted.
"Ultimately, we are interested in identifying predictors of relapse so we can better measure when a person is done with treatment," he said.
This work is supported by the National Institute of Mental Health.
Co-authors include Michael Vilensky, Jacqueline Heath, Casaundra Harbaugh, Adam Buffington and Vasey's principal collaborator, Russell Fazio, all of Ohio State's Department of Psychology.
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Journal Reference:
Michael W. Vasey, Michael R. Vilensky, Jacqueline H. Heath, Casaundra N. Harbaugh, Adam G. Buffington, Russell H. Fazio. It was as big as my head, I swear!. Journal of Anxiety Disorders, 2012; 26 (1): 20 DOI: 10.1016/j.janxdis.2011.08.009
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
[unable to retrieve full-text content]SPACE.com - For the first time, astronomers have discovered the solid form of tiny carbon spheres in deep space in vast cloud of particles locked in orbit around two distant stars.
[unable to retrieve full-text content]HealthDay - TUESDAY, Feb. 21 (HealthDay News) -- The U.S. Food and Drug Administration plans to take a second look at the weight loss pill Qnexa on Wednesday, after initially rejecting it because of concerns about heart problems and possible birth defects.
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HARARE?? Zimbabwe's President Robert Mugabe turned 88 on Tuesday, joking about reports circulating for years of his imminent demise and vowing to stay in power despite international condemnation of his economic and human rights record.
Mugabe said he was in tip-top shape in an interview with state radio, and made no reference to media reports that he is receiving treatment for prostate cancer in Singapore.
"I have died many times. That's where I have beaten Christ. Christ died once and resurrected once," the devout Catholic Mugabe told the radio broadcaster. "I am as fit as a fiddle."
Mugabe charmed world leaders with his wit and intellect in the early years of his rule, when a relatively rich Zimbabwe was praised for its education and social systems.
But he has since become a pariah in the West, blamed for running the economy into the ground and for massive human rights abuses to keep his grip on power.
Mugabe, one of Africa's longest-serving leaders, said his party ZANU-PF would choose his successor at the right time, but he had no intention of stepping down for now.
'Sit-tight' rulers risk African Spring, Nobel laureate says
"Our members of the party will certainly select someone once I say I am now retiring, but not yet," he said in a separate interview with state TV.
"At this age I can still go some distance, can't I," Mugabe said, laughing, clapping his hands and rocking in his chair.
Abstinence and exercise
He put his longevity down to rising at 5 a.m. for a daily exercise routine, abstinence from alcohol and tobacco and a balanced diet.
"There are things one must do for oneself. Don't drink at all, don't smoke, you must exercise and eat vegetables and fruit," he said.
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Asked whether his party still had anything more to offer after more than three decades in power, Mugabe said ZANU-PF's signature policies remained the defense of political independence and the pursuit of black economic empowerment.
Critics say ZANU-PF has helped ruin one of Africa's most promising economies with its seizures and distribution of white-owned commercial farms, and its more recent drive to force foreign-owned firms to transfer majority shareholdings to Zimbabweans.
Mugabe has shared power with his long-time foe, Prime Minister Morgan Tsvangirai, over the last three years after violent and disputed elections in 2008.
Head of Anglican church confronts Mugabe
Mugabe has been nominated as ZANU-PF party's candidate and intends to run in an election he wants held this year.
That would be a year ahead of schedule under the power-sharing deal which also calls for a new constitution to be drawn up and approved ahead of the poll.
"It's not a secret that there is grumbling in the party over his decision to go on and on, but those seeking to succeed him are not strong enough to challenge him," Eldred Masunungure, a political science professor at the University of Zimbabwe, said.
"They are stuck with him for better or worse, and the attitude in ZANU-PF appears to be ? let's hope for the best," Masunungure said.
Video: Godwin: Zimbabwe crying out for international help (on this page)
On Monday, Mugabe repeated his pledge to hold elections this year, even if it means defying South African President Jacob Zuma and other regional leaders who say new polls should be held only after a new democratic constitution is in place.
"This year we must have elections, they must take place with or without a new constitution," Mugabe said in interviews aired by the state broadcaster.
Zuma is tasked by the Southern Africa Development Community to help steer Zimbabwe toward free and fair elections to end the three-year power sharing deal with Tsvangirai that the regional bloc brokered after violent elections in 2008.
Cancer claim
A June 2008 U.S. diplomatic cable released by WikiLeaks last year said
Mugabe had prostate cancer
that had spread to other organs.
His doctor urged him to step down in 2008, according to the cable.
Mugabe, who has ruled the southern African state since its independence from Britain in 1980, chaired a cabinet meeting on Tuesday.
Presidential officials said he would celebrate his birthday at a family dinner at his home in Harare. ZANU-PF is planning a celebration rally in eastern Zimbabwe on Saturday.
Reuters and The Associated Press contributed to this report.
Starting your own Internet marketing business can be exciting and lucrative. With an Internet business, you can work from anywhere you want as long as you have a computer and an Internet connection. There are some steps to follow when starting an Internet business. By following proven Internet marketing start-up tips you can get your business off the ground without much hassle.
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Set up Your Business Website
This is an important step in starting your own online business. You need to have a website to promote your offers. If you have the necessary skills to build a professional-looking website you may create it yourself. Make sure your website is easy to navigate and fast loading. Avoid unnecessary graphics that slow down loading time and possibly even affect your position in the search engines. Include images of the products you offer, and provide detailed and accurate descriptions. If you lack strong web design skills, then hire a web designer to build your site.
Purchase a Domain Name
When starting an Internet marketing business, you will need to purchase a domain name. A domain name is the address of your website. It is important that you choose a domain name that indicates the type of Internet business you have or the type of products or services you sell. Choosing the right name will make it easier for people to find your website on the Internet. So try to choose a domain name based on keywords that can generate search engine traffic to your website.
Select a Web Hosting Service
A web hosting company displays your website to people on the Internet. There are many web hosting companies on the Internet; however, it is important that you choose a reliable hosting provider. You need to thoroughly research the services before signing up with one of them. Look for a reputable company that will provide you with excellent customer support 24 hours a day, 7 days a week. Once you have signed up for a hosting service, you will need to upload your website files to your web host?s server. This is a simple process as there are many programs that can help you with this step. Your web host will give you instructions on how to upload your website files to their server.
Advertise Your Business
Once your website is online, you need to start spreading the word about your Internet business. There are several options available to you. These include article marketing, forum marketing, pay-per-click advertising, banner ads, email marketing, online classified advertising, and social networking, such as Facebook, MySpace and Twitter. Also, it?s a good idea to promote your business locally, letting friends and relatives know about your business. You may need to get an Internet marketing guide created by someone who has become successful in the Internet marketing business. A proven guide or resource can serve as your blueprint as you start and run your own business on the Internet. Keep in mind that the money you can make from your Internet marketing business is tied to the number of visitors to your website.
Guest article written by: Donald Oh is a freelance writer and regular contributor to Key Insurance Quotes.com and spends his free time perusing Reddit.
We all know that, it is obvious. What else would you call the seven days which follow an accident? And how, barring the end of the world, would you not have a first week? But that is not the message of this piece.
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The first week following an accident is a one-time period for opportunity. A diligent employer can, in those first seven days, shape the outcome of a claim so that all (in this case, the employer and employee) will benefit. The ?losers? will be those who stand to gain from inefficiency, which is to say, everyone else in the claims process. [WCx]
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Why is the first week so important? The law requires some things to be done rather quickly (filing an employer?s report of injury) but most can surely wait until the carrier does them ? can?t they? The technical answer is, ?Yes.??The smart answer is, ?No!?
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Every claim does have a first week- but none have two of them. Once the first week passes without action it can never be regained ? and the first week is exclusively the employer?s. A carrier cannot effectively get started defending a claim until several weeks passes from when it is notified.
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What should the employer do in this period? Oversee the care of the employee and gather facts. The first is not optional ? at least not in NY.
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?Most people who work in the comp field in NY are surprised to learn that the comp law places an affirmative responsibility on the part of the EMPLOYER (no one else is mentioned) to see that an injured employee receives proper medical care. ?That does not mean selecting a treating doctor (although that was actually done in the first decades of the comp law), but it does mean that the employer should not be passive if the employee is obviously not getting the treatment needed.
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The other responsibility which should be attended to by the employer is gathering a forwarding (to the Board, the carrier, the treating doctor and the worker) information and documents which will be needed (payroll, details of accident) or which might be needed (prior injuries, claims, employers, medical plans, periods of significant absence, etc.).
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The last, documents which might be needed, puzzles many employers. If the information is not requested, why would it ever be needed? The answer is that if others do not know the information exists ? why would they request it? True, they should ask what other information exists ? but in the real world they usually do not. Nothing will increase an x-mod faster than the useful information which remains silent and uninvited, sitting in a file cabinet drawer (or in cyberspace).
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Finally, there is the therapeutic aspect of purposeful activity. A worker, and the worker?s family, is all too frequently struggling through a morass of silence and indifference during the first weeks. The person closest to them, the employer, seems to be uninvolved in the claim. Many employers are under the impression that they are REQUIRED to be out of the loop. ?The carrier has to do that.? In truth, the comp law mentions the employer frequently and the carrier hardly at all ? except as surety for payment of awards. [WCx]
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In short, it is difficult for an employer to be over involved in a claim. Or over concerned about the welfare of an employee. And the best time to become involved and concerned is ? the first week.
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Author: Attorney Theodore Ronca is a practicing lawyer from Aquebogue, NY. He is a frequent writer and speaker, and has represented employers in the areas of workers? compensation, Social Security disability, employee disability plans and subrogation for over 30 years. Attorney Ronca can be reached at 631-722-2100. medsearch7@optonline.net
Do not use this information without independent verification. All state laws vary. You should consult with your insurance broker or agent about workers comp issues.
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?2012 Amaxx Risk Solutions, Inc. All rights reserved under International Copyright Law. If you would like permission to reprint this material, contact us at: Info@ReduceYourWorkersComp.com.
This entry was posted on Sunday, February 19th, 2012 at 5:35 pm and is filed under Claim Management, Communication with Employees, Litigation Management, Settling WC Claims, WC 101. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.
[unable to retrieve full-text content]Reuters - China's central bank said on Saturday it would cut the reserve requirement ratio (RRR) for banks by 50 basis points, effective from February 24.
It takes a unique form of person to be a nurse, and a person much more centered on specialize in something needs these phones have more schooling through nurse continuing education programs. Nurses should be nurturing, but will even capable of techniques to people knowing they might be creating them tenderness ? whether or not it is for that increased good quality in regards to which person?s well being. Nurses could be LPN or Health care worker, but some move on with training in order to give much more specialized care. If you are directly into medical, take into account what you can do if you think maybe a more extreme career is for an individual.
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As fencers develop technically and tactically, their training should progressively resemble the circumstances they?ll face competing. Clearly, elevated focus on fencing practice bouts is a element of this transition. However, drills remain important in an effort to build the amount of repetitions of abilities required to develop high amounts of proficiency. Within this training atmosphere, the bouting drill provides a helpful accessory for training.
Created for intermediate and advanced fencers, the bouting drill continues to have a restricted quantity of technical choices, a couple of attacks and a couple of protection. However, the drill itself more carefully resembles a bout:
(1) The coach identifies the experience and reaction for that drill by supplying the particular techniques to be used.
(2) The fencers begin in a conventional exchange drill of countless cycles to create their technical execution to readiness. This area of the drill shouldn?t be prolonged, as technical perfection isn?t the goal. Rather the fencer ought to be psychologically prepared to fight and also have the particular skill inside an acceptable selection of performance. One way possible to bound this really is to limit the amount of repetitions to that particular which may fit the bill being an immediate pre-bout warm-up competing.
(3) Then your drill transitions by getting rid of the exchange feature. Now either fencer can advance or retreat, attack, defend, or counterattack. Who initiates and who responds is dependent greatly around the initiative and fighting spirit from the fencers.
(4) Soon after a success is obtained, the fencers take distance and resume the experience. This might be done in the place on the ground in which the hit happened. A far more realistic choice is revisit the on guard lines to resume the drill.
This drill could be run for any set period of time throughout the audience lesson. Realism is elevated when the drill operates until one fencer scores 5 valid touches or maybe no more than 3 minutes running time is permitted. Immediate rotation to utilize a brand new partner turns into a simulation from the rapid pace of bouts inside a pool that?s being double removed and boosts the stress degree of the drill.
The bouting drill is a step lacking the practice bout. By restricting the strategy for use, still it concentrates on technical development and forces the fencers to create the particular abilities operate in a mobile atmosphere. However, the free play component of the drill models conditions around the strip inside a competition, which realism could be enhanced by setting a little limit, imposing a period limit, and rotating the participants.
[unable to retrieve full-text content]AP - Spending on two of the Pentagon's top priorities, cybersecurity and special operations forces, would largely remain flat or dip slightly in 2013 under the Defense Department's budget proposal, as officials beef up personnel and research but find savings elsewhere.
As diabetes emerges, researchers track disease's first stepsPublic release date: 16-Feb-2012 [ | E-mail | Share ]
Contact: Tom Rickey tom_rickey@urmc.rochester.edu 585-275-7954 University of Rochester Medical Center
Scientists have taken a remarkably detailed look at the initial steps that occur in the body when type 1 diabetes mellitus first develops in a child or young adult.
The analysis comes from a team of researchers and physicians at the University of Rochester Medical Center who have expertise both in the laboratory and in treating patients. The team studied children from ages 8 to 18 within 48 hours of their diagnosis with type 1 diabetes, an autoimmune disease where the body's immune system attacks the cells in the pancreas that make insulin.
The incidence of the disease is rising quickly and has roughly doubled during the last 20 years or so. Approximately 30,000 children each year in the United States are diagnosed with the disease, according to the American Diabetes Association.
The trend is noticeable to pediatrician Nicholas Jospe, M.D., chief of Pediatric Endocrinology at Golisano Children's Hospital of the University of Rochester Medical Center, and his colleagues nationwide. His group now sees about 90 new cases of type 1 diabetes per year, compared to approximately 25 annually 20 years ago.
Every day, at the eastern end of the medical center, Jospe counsels families and children coping with the condition. At the same time, in a labyrinth of laboratories situated nearly half a mile to the west under the same roof, immunologists like Deborah J. Fowell, Ph.D., use an array of high-tech equipment to interrogate the likes of T-cells and macrophages for answers about the workings of the immune system.
For the current study, published in the journal Diabetes, Fowell and Jospe pooled their strengths to look at the disease in a way impossible to do alone. While scientists know diabetes is becoming more common, they don't understand what factors trigger it, why some children are more prone to getting it, or even why it's becoming more common.
Important clues lie within the so-called "honeymoon phase" in newly diagnosed patients, a period when the disease is more easily controlled in patients than at any other time.
While diabetes never fully goes away unlike other autoimmune diseases that cycle through remissions and relapses it is marked by a single, early remission phase that starts within weeks of diagnosis and lasts a year or two. During this time, patients are healthy and don't need much insulin to control the disease. This honeymoon period is central to today's efforts to develop new treatments: Most current new treatments in development are aimed at these crucial first months.
"This is a period of great interest," said Jospe. "During this period, blood glucose levels actually normalize more than at any other time, and patients do not require that much insulin; it's as though the body were still producing insulin. But we do not understand the nature of this remission, and that is holding the field back.
"If we knew what was happening, perhaps we could replicate it or prolong it for the benefit of the patient. Most treatments today attempt to do just that prolong the honeymoon period. But there has not been much success thus far," added Jospe.
In a hunt for answers, Jospe teamed with Fowell, associate professor of Microbiology and Immunology and a scientist in the Center for Vaccine Biology and Immunology. For Fowell, the corresponding author of the team's report, an important dimension of her research is translating its findings on the basic regulation of immune cells into a better understanding of immunity in human autoimmune disease.
"Making research relevant for patients improving their lives through new research findings is not as straightforward as making a finding in the lab, then trying it out in people," said Fowell. "Rather, it involves analyzing laboratory findings and then taking a closer look in people, while simultaneously studying patients and bringing those observations to the laboratory to help shape experiments there. This is what Nick and I are doing learning from each other as we go to learn more about diabetes."
Fowell's group analyzed several measures of the immune system during the year after diagnosis in 21 children with type 1 diabetes, as well as in 22 healthy children and 70 healthy adults.
The team focused on immune cells known as T-regulatory cells, powerful cells that control how many other immune cells work. They help determine how the body responds to infection and vaccination, and they play the role of super cops of the immune system, disarming immune cells that mistakenly attack the body's own tissues. Fowell is an expert on "T-regs" and highlighted their role in a recent paper in the Proceedings of the National Academy of Sciences.
Since T-regulatory cells are among those charged with suppressing errant immune cells, exploring their function is an important part of understanding autoimmune diseases like diabetes, where the immune system is out of control.
The team found a great deal of variability among the children. In some, T-regulatory cells appeared to function normally throughout the remission period, while in others, activity appeared low throughout. In still other children, activity dipped during the honeymoon phase but then bounced back.
At the same time, the team witnessed an increase in activity of immune-boosting "effector cells," and increases in cytokines for interleukin 17 and tumor necrosis factor. Such chemical signaling molecules play a key role protecting us from pathogens, but in autoimmune diseases they have a hand in causing tissue damage in diabetes, for instance, helping to incite the immune attack that destroys the insulin-producing cells in the pancreas.
The mix of results can be interpreted in many ways, said Jospe. One possibility is that the immune system is producing rogue immune cells that can't be well controlled by the T-regulatory cells. Another possibility is that the function of the T-regulatory cells is not up to par, giving wayward cells the opportunity to harm the body.
Jospe and Fowell are hopeful that the results, a series of molecular snapshots of immune activity in patients, will contribute to a better understanding of the disease.
"One hope, of course, is to create better treatments for patients. Another possibility is to find biomarkers to identify children who are at extra risk of developing type 1 diabetes," said Jospe.
###
The study was supported in part by the University's Autoimmunity Center of Excellence, funded by the National Institute of Allergy and Infectious Diseases.
In addition to Fowell and Jospe, other authors of the paper include Angela Hughson and Irina Bromberg in the Fowell laboratory, nurse Barbara Johnson of the Division of Pediatric Endocrinology, and Sally Quataert, Ph.D., research associate professor of Microbiology and Immunology.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
As diabetes emerges, researchers track disease's first stepsPublic release date: 16-Feb-2012 [ | E-mail | Share ]
Contact: Tom Rickey tom_rickey@urmc.rochester.edu 585-275-7954 University of Rochester Medical Center
Scientists have taken a remarkably detailed look at the initial steps that occur in the body when type 1 diabetes mellitus first develops in a child or young adult.
The analysis comes from a team of researchers and physicians at the University of Rochester Medical Center who have expertise both in the laboratory and in treating patients. The team studied children from ages 8 to 18 within 48 hours of their diagnosis with type 1 diabetes, an autoimmune disease where the body's immune system attacks the cells in the pancreas that make insulin.
The incidence of the disease is rising quickly and has roughly doubled during the last 20 years or so. Approximately 30,000 children each year in the United States are diagnosed with the disease, according to the American Diabetes Association.
The trend is noticeable to pediatrician Nicholas Jospe, M.D., chief of Pediatric Endocrinology at Golisano Children's Hospital of the University of Rochester Medical Center, and his colleagues nationwide. His group now sees about 90 new cases of type 1 diabetes per year, compared to approximately 25 annually 20 years ago.
Every day, at the eastern end of the medical center, Jospe counsels families and children coping with the condition. At the same time, in a labyrinth of laboratories situated nearly half a mile to the west under the same roof, immunologists like Deborah J. Fowell, Ph.D., use an array of high-tech equipment to interrogate the likes of T-cells and macrophages for answers about the workings of the immune system.
For the current study, published in the journal Diabetes, Fowell and Jospe pooled their strengths to look at the disease in a way impossible to do alone. While scientists know diabetes is becoming more common, they don't understand what factors trigger it, why some children are more prone to getting it, or even why it's becoming more common.
Important clues lie within the so-called "honeymoon phase" in newly diagnosed patients, a period when the disease is more easily controlled in patients than at any other time.
While diabetes never fully goes away unlike other autoimmune diseases that cycle through remissions and relapses it is marked by a single, early remission phase that starts within weeks of diagnosis and lasts a year or two. During this time, patients are healthy and don't need much insulin to control the disease. This honeymoon period is central to today's efforts to develop new treatments: Most current new treatments in development are aimed at these crucial first months.
"This is a period of great interest," said Jospe. "During this period, blood glucose levels actually normalize more than at any other time, and patients do not require that much insulin; it's as though the body were still producing insulin. But we do not understand the nature of this remission, and that is holding the field back.
"If we knew what was happening, perhaps we could replicate it or prolong it for the benefit of the patient. Most treatments today attempt to do just that prolong the honeymoon period. But there has not been much success thus far," added Jospe.
In a hunt for answers, Jospe teamed with Fowell, associate professor of Microbiology and Immunology and a scientist in the Center for Vaccine Biology and Immunology. For Fowell, the corresponding author of the team's report, an important dimension of her research is translating its findings on the basic regulation of immune cells into a better understanding of immunity in human autoimmune disease.
"Making research relevant for patients improving their lives through new research findings is not as straightforward as making a finding in the lab, then trying it out in people," said Fowell. "Rather, it involves analyzing laboratory findings and then taking a closer look in people, while simultaneously studying patients and bringing those observations to the laboratory to help shape experiments there. This is what Nick and I are doing learning from each other as we go to learn more about diabetes."
Fowell's group analyzed several measures of the immune system during the year after diagnosis in 21 children with type 1 diabetes, as well as in 22 healthy children and 70 healthy adults.
The team focused on immune cells known as T-regulatory cells, powerful cells that control how many other immune cells work. They help determine how the body responds to infection and vaccination, and they play the role of super cops of the immune system, disarming immune cells that mistakenly attack the body's own tissues. Fowell is an expert on "T-regs" and highlighted their role in a recent paper in the Proceedings of the National Academy of Sciences.
Since T-regulatory cells are among those charged with suppressing errant immune cells, exploring their function is an important part of understanding autoimmune diseases like diabetes, where the immune system is out of control.
The team found a great deal of variability among the children. In some, T-regulatory cells appeared to function normally throughout the remission period, while in others, activity appeared low throughout. In still other children, activity dipped during the honeymoon phase but then bounced back.
At the same time, the team witnessed an increase in activity of immune-boosting "effector cells," and increases in cytokines for interleukin 17 and tumor necrosis factor. Such chemical signaling molecules play a key role protecting us from pathogens, but in autoimmune diseases they have a hand in causing tissue damage in diabetes, for instance, helping to incite the immune attack that destroys the insulin-producing cells in the pancreas.
The mix of results can be interpreted in many ways, said Jospe. One possibility is that the immune system is producing rogue immune cells that can't be well controlled by the T-regulatory cells. Another possibility is that the function of the T-regulatory cells is not up to par, giving wayward cells the opportunity to harm the body.
Jospe and Fowell are hopeful that the results, a series of molecular snapshots of immune activity in patients, will contribute to a better understanding of the disease.
"One hope, of course, is to create better treatments for patients. Another possibility is to find biomarkers to identify children who are at extra risk of developing type 1 diabetes," said Jospe.
###
The study was supported in part by the University's Autoimmunity Center of Excellence, funded by the National Institute of Allergy and Infectious Diseases.
In addition to Fowell and Jospe, other authors of the paper include Angela Hughson and Irina Bromberg in the Fowell laboratory, nurse Barbara Johnson of the Division of Pediatric Endocrinology, and Sally Quataert, Ph.D., research associate professor of Microbiology and Immunology.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
BEIJING ? Chinese Vice President Xi Jinping's U.S. visit this week shows he is all but certain to take over as China's next leader, but back home the competition is rough for the other top slots to run the country with him.
One contender, Bo Xilai, has been enveloped in a scandal involving unconfirmed reports of malfeasance by his former police chief. That has raised talk of a conspiracy to humiliate the flamboyant Bo and push the Chongqing city Communist Party boss out of contention.
Heavy turnover this year on the party's leading bodies and the lack of a strong leader are fueling battles for places that defy the Chinese preference for quiet backroom deals and public consensus, China experts say. Bo Xilai isn't the first, and may not be the last, to suffer attacks whose origins remain obscure even to insiders, they say.
"Sometimes in power struggles, you can't attack the person directly, so you try to undermine the person by attacking associates and family members. It's never quite clear where the attacks come from," said Bo Zhiyue, an expert on the Chinese leadership at the National University of Singapore. He is not related to the Chongqing party chief.
The Communist Party's rules on succession have never been clearly stated, a reflection of its secretive, topdown nature.
What is known is that the party will designate a new group of elite leaders this fall as part of a transition which began five years ago with the tacit designation of Xi as future party chairman and national president by his appointment to a top spot on the Politburo Standing Committee. He became the highest-ranking member who would still be short of retirement age during the next leadership turnover.
Current President Hu Jintao was dispatched to the U.S. on a similar visit shortly before taking power, so Xi's trip is widely seen as confirming his status as future leader.
Over several days in October, the party's 300 Central Committee members will discuss policy and select a Politburo ? which now stands at 25 members ? along with its all-powerful Standing Committee, seven of whose nine members are due to stand down because of an unstated retirement of about 67.
Whether the top leadership is selected by internal vote, direct appointment, or mutual agreement isn't known. While age and experience are strongly valued, raw power and forcefulness are as important as technical competence.
No strongman has emerged with enough influence to force through positions in the manner of Mao Zedong or Deng Xiaoping, who tipped Hu to take over as eventual leader back in 2003, over the head of then-president Jiang Zemin. Hu will retire this fall.
"In the past, someone strong would have stepped in to settle matters," said Ding Xueliang, a China politics expert at Hong Kong's University of Science and Technology, speaking both of the Bo Xilai affair and the succession in general. "That's all changed now."
The 80 million-member party needs to seek a balance between rival interests, said Ding and others. Presently, the leadership is dominated by hard-liners led by Hu and parliamentary boss Wu Bangguo.
They tend to favor the economy's state sector, strong suppression of dissent and alliances with other authoritarian regimes, said China expert Feng Chongyi of Australia's University of Technology in Sydney.
Xi, 58, is seen as a consensus choice defined by his pragmatism, but he also is considered to lean toward the private sector, a strong legal system, and friendships with democracies such as the U.S., Feng said.
He's also representative of the party "princelings," whose careers have been helped by their family connections to communist elders.
Li Keqiang, tipped as the next premier, is from the party's populist wing, associated with Hu's party youth wing faction but not considered a strong conservative, Feng said.
Adding to the competition, former leader Jiang is also seeking to preserve his influence through moderate candidates for leadership positions, such as Tianjin city party chief Zhang Gaoli and Public Security Minister Meng Jianzhu.
The scale of the leadership turnover and intensity of the competition make this year's succession especially challenging, China watcher Cheng Li of the business-oriented Brookings Institution in Washington wrote in a recent study.
Xi and the others who take over the party later this year ? and who will be formally promoted to their government posts next spring ? will have to deal with severe challenges such as discontented migrant workers, rapid urbanization, pollution, corruption and ethnic unrest.
There is a risk that divisions over personnel and policy could cause paralyze the new leadership's decision-making, Li said. With the economy slowing and unrest simmering in parts of the country, that could pose real dangers, he wrote. Beijing would have few tools to respond to greater unrest other than greater repression.
In recent months, anti-government violence has risen in Xinjiang and in Tibetan areas, where 20 Buddhist monks, nuns and laypeople have set themselves on fire in protests against official policies.
Although Bo Xilai's future has yet to be decided, recent events show how quickly political winds can shift in China.
Unconfirmed media reports say an investigation into abuse of power has targeted Chongqing's former top policeman Wang Lijun, who had been closely linked with Bo and oversaw a crackdown on gangs and corrupt officials on Bo's behalf.
That campaign won Bo and Wang national attention and fueled speculation Bo was angling for a Politburo Standing Committee seat. But Wang has not been heard from since he visited the U.S. consulate in the city of Chengdu more than a week ago, possibly a failed bid for asylum. The incident harms Bo by showing him as unable to control his subordinates and taints him by association with alleged abuse of power.
"The least we can say is that Bo is now in trouble, if not completely out of the running," said Ding, of Hong Kong's University of Science and Technology.
A frequently quoted expert on small business lending and recently named the ?Top Entrepreneur of 2011? by Crain?s New York Business, Rohit Arora is CEO of Biz2Credit, which connects small business owners with 400 lenders, credit rating agencies and service providers. Since 2007, Biz2Credit has secured $400 million in funding for small businesses across the U.S. via its safe, efficient online platform. 
Starting your own Internet marketing business can be exciting and lucrative. With an Internet business, you can work from anywhere you want as long as you have a computer and an Internet connection. There are some steps to follow when starting an Internet business. By following proven Internet marketing start-up tips you can get your business off the ground without much hassle. 
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Public release date: 16-Feb-2012
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